New paper: A Prothrombotic Score Based on Genetic Polymorphisms of the Hemostatic System Differs in Patients with IS, MI, or PAOD

My first paper in frontiers of cardiovascular medicine, an open access platform focussed on cardiovascular medicine. This is not a regular case-control study, where the prevelance of a risk factor is compared between an unselected patient group and a reference group from the general population. No, this paper takes patients with cardiovascular disease who are referred for thrombophilia testing. when the different diseases (ischemic stroke vs myocardial infarction / PAOD) are then compared in terms of their thrombophilic propensity, it is clear that these two groups are different. The first culprit to think might be that thrombophilia indeed plays a different role in the etiology of these disease, like we demonstrated in a RATIO publication as well as this systematic review, but it might also be that there is just a different referral pattern. in any case, it indicates that the role of thrombophilia – whether it is causal or physician suspected – is different between the different forms of arterial thrombosis.